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Search Results for " protac i "

17

Compounds

Cat No. Product Name Synonyms Targets
T34168 PROTAC-I PROTAC I
PROTAC-I targets steroid hormone receptors for ubiquitination and degradation.
T13086 I-BET762 carboxylic acid Molibresib carboxylic acid,PROTAC BRD4-binding moiety 2,GSK525762A carboxylic acid Epigenetic Reader Domain
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T40000 Pomalidomide-C3-I Others
Pomalidomide-C3-I is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
T40008 Pomalidomide-C6-I TFA Others
Pomalidomide-C6-I TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
T39901 PROTAC IRAK4 degrader-4 PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T74411 PROTAC IRAK4 degrader-7
PROTAC IRAK4 degrader-7 (Compound I-417) is an orally administered agent with antitumor properties, functioning as a PROTAC IRAK4 degrader [1].
T39679 Lenalidomide-I
Lenalidomide-I (Compound 72) is a derivative of the cereblon (CRBN) ligand, Lenalidomide, with affinity for E3 ubiquitin ligase. It facilitates the recruitment of CRBN protein. Lenalidomide-I can be utilized in PROTACs, ...
T39315 I-PEG5-OH I-PEG5-OH
I-PEG5-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within ...
T38772 I-PEG6-OH I-PEG6-OH
I-PEG6-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within ...
T74454 JPS016
JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC). It serves as a potent HDAC1/2 degrader, resulting in a signific...
T74456 JPS036
JPS036, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), efficiently degrades class I histone deacetylase (HDAC), particularly HDAC1/2. Its activity results in a substantial inc...
T77938 JPS016 TFA HDAC
JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a substa...
T78956 PROTAC BRD3/BRD4-L degrader-2 Epigenetic Reader Domain
PROTAC BRD3/BRD4-L degrader-2, a PROTAC molecule, selectively degrades cellular BRD3 and BRD4-L with K i values of 16.91 and 2.8 nM, respectively, and exhibits robust antitumor activity in mouse xenograft models, serving...
T74453 JPS014
JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is ...
T77937 JPS014 TFA HDAC
JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a hi...
T74455 JPS035
JPS035, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), specifically HDAC1/2. Its potent activity is associated with an...
T79034 GXF-111 Epigenetic Reader Domain
GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins. It exhibits high binding affinities to both BRD3 BD1 and BRD3 BD2, with K i value...
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